The former logo of the UFC, used from to Early competition: The tournament was inspired by the Gracies in Action video-series produced by the Gracie family of Brazil which featured Gracie jiu-jitsu students defeating martial-arts masters of various disciplines such as karate , kung fu , and kickboxing. The tournament would also feature martial artists from different disciplines facing each other in no-holds-barred combat to determine the best martial art and would aim to replicate the excitement of the matches Davie saw on the videos. Davie drafted the business plan and twenty-eight investors contributed the initial capital to start WOW Promotions with the intent to develop the tournament into a television franchise. Art Davie functioned as the show's booker and matchmaker. Royce Gracie's submission skills proved the most effective in the inaugural tournament, earning him the first ever UFC tournament championship  after submitting Jimmerson, Shamrock, and Gordeau in succession.
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Abstract The term congenital neutropenia encompasses a family of neutropenic disorders, both permanent and intermittent, severe When neutropenia is detected, an attempt should be made to establish the etiology, distinguishing between acquired forms the most frequent, including post viral neutropenia and auto immune neutropenia and congenital forms that may either be isolated or part of a complex genetic disease. Except for ethnic neutropenia, which is a frequent but mild congenital form, probably with polygenic inheritance, all other forms of congenital neutropenia are extremely rare and have monogenic inheritance, which may be X-linked or autosomal, recessive or dominant. About half the forms of congenital neutropenia with no extra-hematopoetic manifestations and normal adaptive immunity are due to neutrophil elastase mutations. Some patients have severe permanent neutropenia and frequent infections early in life, while others have mild intermittent neutropenia. Congenital neutropenia may also be associated with a wide range of organ dysfunctions, as for example in Shwachman-Diamond syndrome associated with pancreatic insufficiency and glycogen storage disease type Ib associated with a glycogen storage syndrome. So far, the molecular bases of 12 neutropenic disorders have been identified.
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